Emotherapy, and adjuvant chemotherapy, but should be combined with radiotherapy and just after surgery, while the approach of radiotherapy and surgery have been no limitations; (iii) the overall survival (OS) or the recurrence-free survival (RFS) must be compared between two interventions or interventions and placebo. Besides, though some trials satisfied the inclusion conditions, considering the fact that they carried out between unique methods of administration in the identical drug or the intervention they investigated which can not kind a loop, they were nevertheless excluded eventually. The trials incorporated should really also meet PRISMA guidelines. Based on these criteria, two reviewers screened titles and abstracts of all retrieved articles, plus the complete texts would be examined respectively when essential. And any arguments could be solved under discussion by the panel.impactjournals.com/oncotargetAbbreviationsHPV (human papillomavirus); RCTs (Randomized controlled trials); OS (general survival); RFS (recurrencefree survival); HR (hazard ratio); OR (odds ratio); CIOncotarget(self-assurance interval); SUCRA (surface beneath cumulative ranking curve); HPV (human papillomavirus); FIGO (Federation of Gynecology and Obstetrics); RCTs (randomized handle trials); MA (meta-analyses); NMA (network meta-analysis); dUMP(deoxyuridine monophosphate); CrIs (credible intervals); Ble (Bleomycin); Cis (Cisplatin); Doc (Docetaxel); Epi (Epirubicin); Flu (Fluorouracil); Hyd (Hydroxyurea); Ifo (Ifosfamide); MitoC (Mitomycin C); Pac (Paclitaxel); Vbl (Vinblastine); Vcr (Vincristine).16,563 women with cervical carcinoma and 33,542 ladies without the need of cervical carcinoma from 25 epidemiological research. Int J Cancer. 2006; 119:11084. 10. Lanciano RM, Won M, Hanks GE. A reappraisal from the International Federation of Gynecology and Obstetrics staging method for cervical cancer. A study of patterns of care. Cancer. 1992; 69:4827. 11. Beiner ME, Covens A. Surgery insight: radical vaginal trachelectomy as a process of fertility preservation for cervical cancer. Nat Clin Pract Oncol. 2007; four:3531. 12. Dische S. Radiotherapy of cervical cancer. Clin Obstet Gynaecol. 1985; 12:2037. 13. Eifel PJ, Winter K, Morris M, Levenback C, Grigsby PW, Cooper J, Rotman M, Gershenson D, Mutch DG. Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of radiation therapy oncology group trial (RTOG) 90-01. J Clin Oncol. 2004; 22:8720. 14. Whitney CW, Sause W, Bundy BN, Malfetano JH, Hannigan EV, Fowler WC Jr, Clarke-Pearson DL, Liao SY.Leptin Protein Formulation Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma from the cervix with damaging paraaortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study.MDH1 Protein manufacturer J Clin Oncol.PMID:23907521 1999; 17:13398. 15. Kim HS, Sardi JE, Katsumata N, Ryu HS, Nam JH, Chung HH, Park NH, Song YS, Behtash N, Kamura T, Cai HB, Kim JW. Efficacy of neoadjuvant chemotherapy in patients with FIGO stage IB1 to IIA cervical cancer: an international collaborative meta-analysis. Eur J Surg Oncol. 2013; 39:11524. 16. Rydzewska L, Tierney J, Vale CL, Symonds PR. Neoadjuvant chemotherapy plus surgery versus surgery for cervical cancer. Cochrane Database Syst Rev. 2012; 12:CD007406. 17. Eddy GL, Bundy BN, Creasman WT, Spirtos NM, Mannel RS, Hannigan E, O’Connor D. Remedy of (“bulky”) stage IB cervical cancer with or with out neoadjuvant vincristine and cisplatin pri.
