Pplemental files. The tissue investigated for this study is archived in the Institute of Pathology from the Technical University of Munich. Acknowledgments: We thank the Comparative Experimental Pathology Unit in the Institute of Pathology and specially Marion Mielke and Olga Seelbach for excellent technical assistance. Furthermore, we thank Simone K pel and Christina Schott from the Biobank with the Klinikum rechts der Isar (MTBio) for their great support. Conflicts of Interest: The authors declare no conflict of interest.
cancersReviewPeutz eghers Syndrome and also the Part of Imaging: Pathophysiology, Diagnosis, and Associated CancersSergio Klimkowski 1, , Mohamed Ibrahim 2 , Juan J. Ibarra Rovira 1 , Mohamed Elshikh three , Sanaz Javadi 1 , Albert R. Klekers 1 , Abdelraham A. PF-06873600 medchemexpressCDK https://www.medchemexpress.com/s-pf-06873600.html �Ż�PF-06873600 PF-06873600 Biological Activity|PF-06873600 In Vivo|PF-06873600 custom synthesis|PF-06873600 Autophagy} abusaif 1 , Ahmed W. Moawad 4 , Kamran Ali 2 and Khaled M. Elsayes 1, Division of Abdominal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77555, USA; [email protected] (J.J.I.R.); [email protected] (S.J.); [email protected] (A.R.K.); [email protected] (A.A.A.) Division of Diagnostic and Interventional Radiology, University of Kansas-Wichita, Wichita, KS 67214, USA; [email protected] (M.I.); [email protected] (K.A.) Division of Diagnostic and Interventional Radiology, The University of Texas Medica Branch, Galveston, TX 77555, USA; [email protected] Division of Diagnostic and Interventional Radiology, Mercy Catholic Wellness Technique, Darby, PA 19023, USA; [email protected] Correspondence: [email protected] (S.K.); [email protected] (K.M.E.)Citation: Klimkowski, S.; Ibrahim, M.; Ibarra Rovira, J.J.; Elshikh, M.; Javadi, S.; Klekers, A.R.; Abusaif, A.A.; Moawad, A.W.; Ali, K.; Elsayes, K.M. Peutz eghers Syndrome plus the Role of Imaging: Pathophysiology, Diagnosis, and Linked Cancers. Cancers 2021, 13, 5121. https:// doi.org/10.3390/cancers13205121 Academic Editor: Mary Frances McMullin Received: 9 September 2021 Accepted: eight October 2021 Published: 13 OctoberSimple Summary: The Peutz-Jeghers Syndrome is a uncommon autosomal dominant syndrome characterized by mucocutaneous pigmentations, various gastrointestinal hamartomatous polyps, and an elevated threat of malignancy. Awareness of numerous Peutz-Jeghers Syndrome imaging patterns, linked malignancies, and their complications is vital for correct imaging interpretation and patient management. In this manuscript, we present an overview of this condition, associated malignancies, and imaging surveillance protocols. Abstract: The Peutz-Jeghers Syndrome (PJS) is definitely an autosomal dominant neoplastic syndrome defined by hamartomatous polyps through the gastrointestinal tract, development of characteristic mucocutaneous pigmentations, and an elevated lifetime cancer threat. The majority of situations are resulting from a mutation inside the STK11 gene located at 19p13.3. The U0126 MAPK/ERK Pathway estimated incidence of PJS ranges from 1:50,000 to 1:200,000. PJS carries an elevated threat of malignancies including gastrointestinal, breast, lung, and genitourinary (GU) neoplasms. Individuals with PJS are at a 15- to 18-fold increased malignancy danger relative for the general population. Radiologists have an integral role inside the diagnosis of those patients. Various imaging modalities are utilised to screen for malignancies and complications related with PJS. Awareness of different PJS imaging patterns, connected malignancies, and their complications is vital for precise imaging inte.
