Pplemental files. The tissue investigated for this study is archived in the Institute of LAU159 Purity & Documentation Pathology with the Technical University of Munich. Acknowledgments: We thank the Comparative Experimental Pathology Unit on the Institute of Pathology and especially Marion Mielke and Olga Seelbach for outstanding technical assistance. Additionally, we thank Simone K pel and Christina Schott in the Biobank of your Klinikum rechts der Isar (MTBio) for their great help. Conflicts of Interest: The authors declare no conflict of interest.
cancersReviewPeutz eghers Syndrome and also the Part of Imaging: Pathophysiology, Diagnosis, and Linked CancersSergio Klimkowski 1, , Mohamed Ibrahim two , Juan J. Ibarra Rovira 1 , Mohamed Elshikh 3 , Sanaz BAS 490 F Autophagy Javadi 1 , Albert R. Klekers 1 , Abdelraham A. Abusaif 1 , Ahmed W. Moawad 4 , Kamran Ali two and Khaled M. Elsayes 1, Department of Abdominal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77555, USA; [email protected] (J.J.I.R.); [email protected] (S.J.); [email protected] (A.R.K.); [email protected] (A.A.A.) Division of Diagnostic and Interventional Radiology, University of Kansas-Wichita, Wichita, KS 67214, USA; [email protected] (M.I.); [email protected] (K.A.) Department of Diagnostic and Interventional Radiology, The University of Texas Medica Branch, Galveston, TX 77555, USA; [email protected] Department of Diagnostic and Interventional Radiology, Mercy Catholic Wellness Technique, Darby, PA 19023, USA; [email protected] Correspondence: [email protected] (S.K.); [email protected] (K.M.E.)Citation: Klimkowski, S.; Ibrahim, M.; Ibarra Rovira, J.J.; Elshikh, M.; Javadi, S.; Klekers, A.R.; Abusaif, A.A.; Moawad, A.W.; Ali, K.; Elsayes, K.M. Peutz eghers Syndrome and the Function of Imaging: Pathophysiology, Diagnosis, and Related Cancers. Cancers 2021, 13, 5121. https:// doi.org/10.3390/cancers13205121 Academic Editor: Mary Frances McMullin Received: 9 September 2021 Accepted: 8 October 2021 Published: 13 OctoberSimple Summary: The Peutz-Jeghers Syndrome is usually a uncommon autosomal dominant syndrome characterized by mucocutaneous pigmentations, several gastrointestinal hamartomatous polyps, and an elevated danger of malignancy. Awareness of various Peutz-Jeghers Syndrome imaging patterns, related malignancies, and their complications is vital for precise imaging interpretation and patient management. Within this manuscript, we provide an overview of this condition, related malignancies, and imaging surveillance protocols. Abstract: The Peutz-Jeghers Syndrome (PJS) is an autosomal dominant neoplastic syndrome defined by hamartomatous polyps via the gastrointestinal tract, improvement of characteristic mucocutaneous pigmentations, and an elevated lifetime cancer threat. The majority of cases are on account of a mutation inside the STK11 gene positioned at 19p13.3. The estimated incidence of PJS ranges from 1:50,000 to 1:200,000. PJS carries an elevated risk of malignancies such as gastrointestinal, breast, lung, and genitourinary (GU) neoplasms. Patients with PJS are at a 15- to 18-fold improved malignancy threat relative for the common population. Radiologists have an integral role in the diagnosis of those patients. Numerous imaging modalities are employed to screen for malignancies and complications related with PJS. Awareness of various PJS imaging patterns, related malignancies, and their complications is important for precise imaging inte.
