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Arsenic compounds are essential drugs that have been made use of in both People’s Republic of China as well as the Western globe for additional than two,000 years. Arsenic trioxide (As2O3) and arsenic sulfide (As4S4) were found to have fantastic anti-leukemic activity in particular against acute promyelocytic leukemia (APL).1? As2O3 has a synergistic effect when combined with all-trans-retinoic acid (ATRA). The precise mechanism of such synergistic effect on APL remains incompletely understood, even though it was discovered that thei.
