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Tor phenotype; CRC: Caspase-3 InhibitorMedChemExpress Z-DEVD-FMK colorectal cancer; DAC: 5-Aza-2-deoxycytidine; DFS: Disease-free survival; ESCC: Esophageal squamous cell cancer; GTEx: Genotype-Tissue Expression; HM450: Illumina Infinium Human Methylation 450; IHC: Immunohistochemistry; LOH: Loss of heterozygosity; MSP: Methylation specific PCR; OS: Overall survival; PVDF: Polyvinylidene fluoride; RITA: Rearranged in thyroid adenoma; RPMI: Roswell Park Memorial Institute; RT-PCR: Reverse transcription PCR; TCGA: The Cancer Genome Atlas; TSS: Transcription start sites; ZNF331: Zinc finger protein Acknowledgements We sincerely thank Xiaomo Su and Qi Li for preparing experiments.References 1. Ferlay J, Soerjomataram I, Dikshit R, Eser PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/26100631 S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136:E359?6. 2. Siegel RL, Miller KD, Fedewa SA, Ahnen DJ, Meester RGS, Barzi A, Jemal A. Colorectal cancer statistics, 2017. CA Cancer J Clin. 2017;67:177?3. 3. Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2017;66:683?1. 4. Yan W, Guo M. Epigenetics of colorectal cancer. Methods Mol Biol. 2015;1238:405?4. 5. Gilsing AM, Schouten LJ, Goldbohm RA, Dagnelie PC, van den Brandt PA, Weijenberg MP. Vegetarianism, low meat consumption and the risk of colorectal cancer in a population based cohort study. Sci Rep. 2015;5:13484. 6. Ollberding NJ, Wilkens LR, Henderson BE, Kolonel LN, Le Marchand L. Meat consumption, heterocyclic amines and colorectal cancer risk: the multiethnic cohort study. Int J Cancer. 2012;131:E1125?3. 7. Parr CL, Hjartaker A, Lund E, Veierod MB. Meat intake, cooking methods and risk of proximal colon, distal colon and rectal cancer: the Norwegian Women and Cancer (NOWAC) cohort study. Int J Cancer. 2013;133:1153?3. 8. Bingham SA, Day NE, Luben R, Ferrari P, Slimani N, Norat T, Clavel-Chapelon F, Kesse E, Nieters A, Boeing H, et al. Dietary fibre in food and protectionWang et al. Clinical Epigenetics (2017) 9:Page 12 of9. 10.11.12.13.14.15.16.17.18.19.20.21. 22. 23.24.25.26.27.28. 29.30.31.against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study. Lancet. 2003;361:1496?01. Song M, Garrett WS, Chan AT. Nutrients, foods, and colorectal cancer prevention. Gastroenterology. 2015;148:1244?0. e1216 David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, Ling AV, Devlin AS, Varma Y, Fischbach MA, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014;505:559?3. GD W, Chen J, Hoffmann C, Bittinger K, Chen YY, Keilbaugh SA, Bewtra M, Knights D, Walters WA, Knight R, et al. Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011;334:105?. Rippe V, Belge G, Meiboom M, Kazmierczak B, Fusco A, Bullerdiek J. A KRAB zinc finger protein gene is the potential target of 19q13 translocation in benign thyroid tumors. Genes Chromosomes Cancer. 1999;26:229?6. Wu H, Zhang S, Qiu W, Zhang G, Xia Q, Xiao C, Huang X, Huang M, Agen P, Fan T, et al. Isolation, characterization, and mapping of a novel human KRAB zinc finger protein encoding gene ZNF463. Biochim Biophys Acta. 2001;1518:190?. Dumur CI, Dechsukhum C, Ware JL, Cofield SS, AlM B, Wilkinson DS, Garrett CT, Ferreira-Gonzalez A. Genome-wide detection of LOH in prostate cancer using human SNP microarray technology. G.

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