Incubation of latent p53 with USP7 in EMSAs stimulated sequence-specific DNA binding by latent p53, suggesting that USP7-binding can reverse this autoinhibition. DNA binding by a C-terminal deletion mutant of p53, p5382?sixty, which lacks the USP7 binding sequences, was not stimulated by USP7, suggesting that binding to USP7 is required for this result
The final results over show that USP7 promotes binding of p53 to its goal...